The Smith & Wesson Model 5906 is a pistol manufactured starting in 1989 by Smith & Wesson.

It is seen in the Season 2 finale episode, Twilight (episode) where a terrorist disguised as a Virginia State Trooper uses the gun to kill two Naval officers.

In the Season 3 episode, Jeopardy (episode), drug dealer James Dempsey uses the weapon as a sidearm while holding Director Jennifer Shepard hostage.

In the Season 6 episode, Dead Reckoning (episode), CIA agent Trent Kort takes a Smith & Wesson Model 5906 from a terrorist Kort shot.