In The Missionary Position (episode), it was revealed that she has at least one unnamed sister.
Ryan also helped the team with a case regarding Harper Dearing, a businessman/terrorist who sought revenge against the Navy for the death of his son.
Unfortunately, after Dearing arranged for the release of her ex-husband from jail, Ryan and her young son, Parker were forced to flee. As such, she also permanently ended her relationship with Gibbs much to his dismay.
- Samantha Ryan was portrayed by Jamie Lee Curtis. She and Mark Harmon starred together in the film Freaky Friday.
- During her numerous guest appearances on NCIS, Jamie Lee Curtis was credited as a Special Guest Star.