When the body of Congressman Dan McLane, a former NCIS agent, washes ashore in New Orleans, Gibbs reunites with his former colleague, NCIS Special Agent Dwayne Cassius Pride, in a joint case between the two field offices and the FBI. The teams must work together to determine if the murder was politically based or linked to McLane’s most well-known case, the arrest of the Privileged Killer, a serial murderer who targeted military and public servants.
- Special Agents Dwayne Cassius Pride is introduced for the first time.
- Gibbs and Bishop along with Pride travel to New Orleans where they meet Pride's team of Special Agents Meredith Brody and Christopher LaSalle as well as the local Doctor and Medical Examiner Loretta Wade.
- Zoe McLellan, who appears in this episode as Special Agent Meredith Brody previously appeared in NCIS's parent series, JAG as Petty Officer Jennifer Coates.
|Leroy Jethro Gibbs||Mark Harmon||Special Agent in charge of the Major Case Response Team, NCIS|
|Anthony DiNozzo||Michael Weatherly||Senior Special Agent, MCRT, NCIS|
|Timothy McGee||Sean Murray||Special Agent, MCRT, NCIS|
|Abigail Sciuto||Pauley Perrette||Chief Forensic Specialist,NCIS|
|James Palmer||Brian Dietzen||Assistant Medical Examiner. Credited but did not appear in the episode.|
|Donald Mallard||David McCallum||Chief Medical Examiner, NCIS|
|Leon Vance||Rocky Carroll||Director of NCIS.|
|Eleanor Bishop||Emily Wickersham||NSA Analyst and NCIS Special Agent.|
|Dr. Loretta Wade||C. C. H. Pounder||Jefferson Parish Coroner.|
|Christopher LaSalle||Lucas Black||NCIS Special Agent.|
|Meredith Brody||Zoe McLellan||NCIS Special Agent.|
|Dwayne Cassius Pride||Scott Bakula||NCIS Special Agent in Charge of the NCIS field office in New Orleans. Credited as a Special Guest Star.|
|Tobias Fornell||Joe Spano||Senior Supervisory Agent with the FBI.|
|Abraham Lycek||Andrew St. John||Navy Petty Officer Second Class and Tom Speakman's nephew|
|Tom Speakman||D. C. Douglas||A lobbyist who was campaigning to prevent McLane's reelection|
|Lynette Doyle||Kelsey Scott||FBI Special Agent in New Orleans|
|Linda||Paige Turco||Special Agent D. Pride's wife.|
|Kyle Travers||Trav Lyons||Sheriff's Deputy.|
|Sally Hammond||Vanessa Bell Calloway||Escort|