The Colt Python is a revolver.

It appears in the Season 6 episode, Deliverance (episode).

It appeared in the Season 11/NCIS: New Orleans backdoor pilot episode, Crescent City Part 2 (episode) where it is the second sidearm of NCIS Special Agent Dwayne Cassius Pride with the revolver being given the nickname, "Charmaine" and it's also revealed that Pride has been using the revolver for 25 years.